Intended Use:

AESKUBLOTS Allergy ELEVEN is a membrane-based enzyme immunoassay for quantitative detection of IgE-antibodies against multiple allergens and total IgE in human serum and plasma. Antigens are positioned in parallel lines at exactly defined positions on a nitrocellulose membrane.

This assay is a tool in differential diagnosis of Type I hypersensitivity (allergy).

Coated Antigens:

Egg white (f1), Milk (f199), Wheat (f4), Maize (f8), Sesame (f10), Peanut (f13), Soybean (f14), Walnut (f16), Hazelnut (f17), Almond (f20) , Cashew nut (f204), Shrimp (f24), Venus clam (f242), Scallop (f338), Cod (f3), Tuna (f40), Salmon (f41), CCD* (CCD) and total IgE (IgE) in human Serum or Plasma.

* Cross-reactive carbohydrate determinants (CCD) are protein linked carbohydrate structures present in a wide range of allergens from plants, pollen, mollusks, and insects. IgE antibodies against CCD are present in 25% of patients suffering from allergic symptoms. IgE antibodies against CCD give rise to the impression of polysensitization. Anti-CCD IgE antibodies are not allergen-specific and do not seem to be correlated with clinical symptoms. Multiple positive results in combination with a positive CCD result should be interpreted carefully, and false-positive results due to anti-CCD IgE antibodies should be considered.

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