4002 Vasculitis Pro
AESKUBLOTS Vasculitis Pro is used for the differential diagnosis of autoimmune vasculitis. Antibodies against proteinase 3 (PR3) and myeloperoxidase (MPO) belong to the group of anti-neutrophil cytoplasmic antibodies (ANCA), which have been described as an important marker in the differential diagnosis of autoimmune vasculitis. Anti-PR3 antibodies represent a specific serological marker for granulomatosis with polyangiitis (Wegener's) and could play a role in pathogenesis.
Anti-MPO antibodies occur in idiopathic and vasculitis-associated rapidly progressive glomerulonephritis, they are found in up to 70% of microscopic polyangiitis, and up to 5-50% in the Churg-Strauss syndrome. The serological detection of circulating antibodies against glomerular basement membrane in the glomeruli (GBM) is the method of choice in diagnosis of Goodpasture's syndrome.
PR3, MPO and GBM in human Serum or Plasma.