4002 Vasculitis Pro

Intended Use:

AESKUBLOTS Vasculitis Pro is used for the differential diagnosis of autoimmune vasculitis. Antibodies against proteinase 3 (PR3) and myeloperoxidase (MPO) belong to the group of anti-neutrophil cytoplasmic antibodies (ANCA), which have been described as an important marker in the differential diagnosis of autoimmune vasculitis. Anti-PR3 antibodies represent a specific serological marker for granulomatosis with polyangiitis (Wegener's) and could play a role in pathogenesis.

Anti-MPO antibodies occur in idiopathic and vasculitis-associated rapidly progressive glomerulonephritis, they are found in up to 70% of microscopic polyangiitis, and up to 5-50% in the Churg-Strauss syndrome. The serological detection of circulating antibodies against glomerular basement membrane in the glomeruli (GBM) is the method of choice in diagnosis of Goodpasture's syndrome.

Coated Antigens:

PR3, MPO and GBM in human Serum or Plasma.

Strip Layout:

vasculitis pro blot image s

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